Self-Modifying And Fast Analog Molecular Computing Via Designed Enzymes

Abstract

This work aimed to develop evolvable biological (enzymatic) circuits using designed/engineered proteins that can be made responsive to chosen input stimuli such as small molecule chemicals and/or light. These circuits would operate rapidly and perform complex integration of input signals to produce a desired easily-detectable output. This includes the design and optimization of elementary OR gates using chemical and light inputs, the development and validation of control-theoretic framework for parameter analysis of the designed gates, and the design and implementation of an AND gate. The proteins in each switch were successfully produced and demonstrated the desired input-output function in preliminary experiments. A mathematical framework was also successfully developed to analyze the functioning of each switch and their combinations into elementary logic gates.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2019
Accession Number
AD1087688

Entities

People

  • Eduardo D. Sontag
  • Sagar D Khare

Organizations

  • Rutgers University

Tags

Communities of Interest

  • Energy and Power Technologies
  • Sensors
  • Space

DTIC Thesaurus Topics

  • Air Force
  • Air Force Research Laboratories
  • Chemical Reactions
  • Circuits
  • Department Of Defense
  • Diagrams
  • Dynamic Response
  • Equations
  • Governments
  • Logic Gates
  • Military Research
  • Molecules
  • Networks
  • Optimization
  • Schematic Diagrams
  • Small Molecules
  • Xor Gates

Readers

  • Computer Programming and Software Development.
  • Integrated Circuit Design and Technology.
  • Molecular and Cellular Biochemistry