Drug-Induced Hypothermia Plus Glibenclamide for Rapid, In-Field Treatment of SCI

Abstract

SPECIFIC AIMS: In Aim 1, we will directly compare physical hypothermia and drug-induced hypothermia by DHC, with the goal of demonstrating that in SCI drug-induced hypothermia is therapeutically equivalent to physical hypothermia. In Aim 2,we will directly compare DHC-induced hypothermia vs. glibenclamide, with the goal of demonstrating that in SCI, the combination of the two is superior to either alone. IMPACT: Establishing the safety and benefit of drug-induced hypothermia could greatly expand the use of hypothermia not only in SCI but in traumatic brain injury and other conditions of importance to the mission of the Department of Defense. This proposed study directly impacts the Area of Encouragement: "Pre- hospital, prolonged field care, en route care, and early hospital management of SCI". MILITARY RELEVANCE: The proposed research project, by optimizing in-field and initial critical care treatments, holds the promise of reducing the burden of SCI suffered by military Service members, Veterans, and their family members and caregivers.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2019
Accession Number
AD1088481

Entities

People

  • J. M. Simard

Organizations

  • University of Maryland

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Body Weight
  • Brain Injuries
  • Computers
  • Department Of Defense
  • Health Services
  • Heart Rate
  • Hospitals
  • Hypothermia
  • Information Operations
  • Maryland
  • Patent Applications
  • Professional Development
  • Students
  • Technology Transfer
  • Universities

Fields of Study

  • Medicine

Readers

  • Medical or Health Care Field.
  • Molecular Biology and Genetics
  • Trauma Surgery or Emergency Medicine.