A Rapid Blood Test to Differentiate Latent Tuberculosis from Active Disease

Abstract

The purpose of the study is to develop a blood-based TB test that meets or exceeds WHO Target Product Profiles for a rapid,biomarker-based, non-sputum triage test for detecting active TB disease. To accomplish this, the activities in Year 1 included improvements to the 3-gene mRNA signature, analysis of these improvements, prototype cartridge development, recruitment and blood collection in Moldova, and development of a secure data transmission system. Progress was made toward each of these goals, though validation of the improved signature and prototype cartridge are pending. Enrollment for Aim 2 is occurring at the expected rate. In Year 1 we developed a 9-gene signature that meets WHO TPP minimum criteria. Additional work will be done in Year 2 to improve on this signature and complete the prototype cartridge for validation and field testing.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2019
Accession Number
AD1088483

Entities

People

  • Antonino Catanzaro
  • Laura Myhovich
  • Naomi Hillery
  • Timothy Rodwell

Organizations

  • University of California, San Diego

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • California
  • Computational Biology
  • Data Analysis
  • Data Sets
  • Data Transmission Systems
  • Diseases And Disorders
  • Gene Expression
  • Hematologic Tests
  • Information Science
  • Institutional Review Board
  • Intellectual Property
  • Lung Diseases
  • Medical Personnel
  • Students
  • Supervised Machine Learning
  • Tuberculosis
  • United States

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