Modeling the Impact of Radiation Protectors on Radiation-Induced Sarcoma Risk
Abstract
The threat of a radiation disaster, such as a nuclear accident or terrorist attack, is a growing concern for the military and warrants the development of medical countermeasures to prevent and mitigate acute and delayed radiation injury. We will evaluate the risks of delayed radiation-induced carcinogenesis after radiation alone or in a setting that models radiation protection strategies that block p53-dependent cell death pathways. To reduce radiation-induced cancer risk and to steer development of rationally designed pharmacological agents to mitigate radiation injury, we aim to elucidate the biological drivers of radiation induced late effects. Understanding the link between improved survival of irradiated cells and cancer development will aid in selecting pharmacological strategies that not only prevent acute radiation injury, but also do not increase radiation carcinogenesis, thus improving outcomes for soldiers exposed to radiation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2019
- Accession Number
- AD1088853
Entities
People
- Andrea R. Daniel
- David Kirsch
Organizations
- Duke University