Volumetric Characteristics of Idiopathic Pulmonary Fibrosis Lungs: Computational Analyses of High Resolution Computed Tomography Images of Lung Lobes
Abstract
Background: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease involving progressive degeneration of lung capacity. Current diagnosis of IPF heavily relies on visual evaluation of fibrotic features in high-resolution computed tomography (HRCT) images of the lungs. Although the characteristics of this disease have been studied at the molecular and cellular levels, little is known about the mechanical characteristics of IPF lungs inferred from HRCT images. To this end, we performed a pilot study to investigate the radiographic and volumetric characteristics of lungs in subjects with IPF. Methods: We collected HRCT images of healthy (N = 13) and IPF (N = 9) lungs acquired at breath-holds after full inspiration (expanded state) and full expiration (contracted state). We performed statistical analyses on Hounsfield unit (HU) histograms, lobar volumes (V: lobe volume normalized by the lung volume), and lobar flows (Q: the difference in lobe volume divided by the difference in lung volume between the expanded and contracted states).
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 11, 2019
- Accession Number
- AD1089874
Entities
People
- Anders Wallqvist
- Bora Sul
- Jaques Reifman
- Joanne Cassani
- Lucia Flors
- Michael J. Morris
- Talissa Altes