A Precision Medicine Study of How Inflammation May Underlie the Excessive Burden of Prostate Cancer in Men of African Ancestry

Abstract

Men of African descent experience a disproportionately high prostate cancer mortality. We and others have shown that prostate tumors in African-Americans harbor a distinct immuneinflammation signature. Low-grade inflammation has been described as a prostate cancer risk factor that is associated with aggressive disease. We also reported that regular aspirin use reduces the risk of aggressive prostate cancer and disease recurrence in these men. Together, the observations suggest that a low-grade chronic inflammation related to ancestral factors and tumor biology could be a driver of prostate cancer mortality in men with African ancestry.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2019
Accession Number
AD1089962

Entities

People

  • Stefan Ambs

Organizations

  • Geneva Foundation

Tags

DTIC Thesaurus Topics

  • Acquisition
  • African Americans
  • Biomedical Research
  • Data Acquisition
  • Data Analysis
  • Data Science
  • Department Of Defense
  • Diseases And Disorders
  • Fatty Acids
  • Inflammation
  • Laboratory Procedures
  • Mass Spectrometers
  • Mass Spectrometry
  • Measurement
  • Medical Personnel
  • Neoplasms
  • Observation
  • Personalized Medicine
  • Pilot Studies
  • Prostate
  • Prostate Cancer
  • Risk Factors
  • Tissues

Fields of Study

  • Medicine

Readers

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