Glutamate Neuroexcitotoxicity in GWI

Abstract

The objective of the proposed research is to examine whether dietary exposure to food additives containing glutamate may be contributing to symptoms in Gulf War Illness (GWI). The rationale for proposed study comes from data in the fibromyalgia field which suggests that reducing the consumption of dietary glutamate can reduce over-excitation in the nervous system, leading to symptom improvement. Since there is almost complete symptom overlap between fibromyalgia and GWI, it is of utmost importance to test this diet as a low-cost treatment option in GWI patients. Thus far, we have enrolled 38 subjects into the study and have 2 more people scheduled for their initial visit this month. Overall, we are still on pace to recruit a total of 40 subjects in the timeline indicated in our SOW.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2019
Accession Number
AD1090531

Entities

People

  • Kathleen F Holton

Organizations

  • American University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Business Administration
  • Clinical Trials
  • Contracts
  • Data Analysis
  • Department Of Defense
  • Electronic Mail
  • Food Additives
  • Glutamates
  • Information Operations
  • Management Personnel
  • Patent Applications
  • Persian Gulf Syndrome
  • Professional Development
  • Students
  • Technology Transfer
  • Training

Readers

  • Clinical Trial Research.
  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.