Mast Cells in Sulfur Mustard Exposure: Novel Targets for Modulation to Develop Therapies Against the Long-Term Health Effects in Gulf War Veterans

Abstract

This Tier 1 Discovery award is focused on identifying a novel immune mechanism of Sulfur mustard [mustard gas; bis(2-chloroethyl) sulfide); SM] pathophysiological effects that could contribute to Gulf War Illness (GWI) mediated through mast cells. Mast cells are well known to contribute to allergic inflammatory diseases, but also have wide ranging effects on many physiological systems that are affected in GWI including pulmonary, dermal, gastrointestinal and nervous systems when activated (e.g. degranulation). Importantly, a role for mast cells has been suggested in the mechanism of vesicating chemical agents-induced inflammatory response, changes in immune parameters and tissue damage.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2019
Accession Number
AD1090534

Entities

People

  • Neera Tewari-Singh

Organizations

  • Michigan State University
  • University of Colorado

Tags

DTIC Thesaurus Topics

  • Albumins
  • Amino Acids
  • Biological Sciences
  • Biomedical Research
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemical Weapons
  • Chemistry
  • Diseases And Disorders
  • Gene Expression
  • Health Services
  • Mast Cells
  • Medical Personnel
  • Mustard Agents
  • Nervous System
  • Nitrogen Mustards
  • Persian Gulf Syndrome
  • Phosgene
  • Skin Diseases
  • Therapy
  • Tissues
  • Vesicants

Fields of Study

  • Biology

Readers

  • Geochemistry
  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Oncology