Vitamin D Supplementation for Prevention of Post-Traumatic Osteoarthritis: Evaluation in Animal and Clinical Models
Abstract
This study evaluated the impact of Vitamin D in prevention and progression of post-traumatic osteoarthritis (PTOA). In animals, we surgically induced osteoarthritis in mice, with supplementation of varying levels of Vitamin D, and evaluated using histology, immunohistochemistry, and micro-CT. We evaluated a clinical cohort of USMA cadets treated for anterior cruciate ligament (ACL) tear, with pre- and post-injury serum 25-hydroxy-Vitamin D levels. Findings from the animal model showed evidence that Vitamin D supplementation may decrease OA in female animals, with histologic change sin animals given one of two supraphysiologic doses of oral Vitamin D. Micro-CT demonstrates greater osteophyte volume in females; immunohistochemistry showed decreased staining of key enzymes that breakdown cartilage with increased Vitamin D supplementation. In the clinical portion, we enrolled 89 cadets and evaluated Vitamin D in ACL injured and control cadet cohorts. We noted a significant difference in baseline Vitamin D by sex, but no differences over time or between injured vs. controls. Interestingly, approximately half the cadets tested had serum Vitamin D levels considered low or low-normal.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2019
- Accession Number
- AD1090599
Entities
People
- Jennifer M. Wolf
Organizations
- University of Chicago