Establishing a Protocol to Culture Primary Hippocampal Neurons

Abstract

The brain is the most complex organ of the body organized in discrete anatomical and functional regions. Cell culture systems are an efficient way to manipulate neuronal cells and evaluate their response. Cells from the hippocampus, the area of the brain associated with learning and memory, are commonly used for primary neuronal cultures. This report describes the steps necessary to establish a primary neuronal culture laboratory and evaluates various culturing techniques of primary hippocampal neuronal cultures to determine the best, most appropriate techniques for guiding current and future Army needs.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2020
Accession Number
AD1090613

Entities

People

  • Ann M. Dileonardi

Organizations

  • United States Army Research Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Albumins
  • Azo Compounds
  • Cell Count
  • Cells
  • Cellular Structures
  • Culture Techniques
  • Cytoskeleton
  • Deoxyribonucleic Acids
  • Department Of Defense
  • Low Density
  • Materials
  • Microscopes
  • Military Research
  • Neuroglia
  • Neurons
  • Phase
  • Proteins

Fields of Study

  • Biology

Readers

  • Computational Modeling and Simulation
  • Microbial Pathology
  • Neuroscience