Intramuscular Pharmacokinetics of Naloxone in the Female African Green Monkey (Chlorocebus aethiops sabeus)

Abstract

We evaluated the pharmacokinetics of intramuscular naloxone at a 10 mg human equivalent dose (HED) in adult female African green monkeys. Absorption was rapid, with time to maximum concentration (Tmax) approximating 8 minutes. The elimination half-life was short, approximating 37 minutes. Intramuscular bolus administration of naloxone in this laboratory non-human primate model exhibited orderly and predictable plasma kinetics that were comparable in both sexes.

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Document Details

Document Type
Technical Report
Publication Date
Dec 18, 2019
Accession Number
AD1091542

Entities

People

  • Jeffrey L. Langston
  • Jennifer R. Makar
  • Katherine N. Bullock
  • M. R. Pennington
  • Todd M. Myers

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

DTIC Thesaurus Topics

  • Absorption
  • Alcohols
  • Alkenes
  • Biomedical Research
  • Blood
  • Elimination
  • Formic Acid
  • Kinetics
  • Laboratory Animals
  • Liquid Chromatography
  • Mass Spectrometers
  • Mass Spectrometry
  • Pharmacokinetics
  • Research Facilities
  • Standards
  • United States
  • Veins

Fields of Study

  • Biology
  • Medicine

Readers

  • Toxicology/Environmental Toxicology