Prevention of the Post-Traumatic Fibrotic Response in Joints: A Critical Preclinical Evaluation of an Antifibrotic Antibody
Abstract
Our addresses the critical clinical problem of posttraumatic joint stiffness, a pathology that reduces the range of motion (ROM) of injured joints and contributes to the development of osteoarthritis. The fundamental hypothesis that drives the current study is that pathological fibrotic response of injured joint tissues may be limited by targeting the formation of collagen fibrils, a main component of the fibrotic mass. Key preliminary data indicate the following: (i) in comparison to the non-treated control, deposition of newly-formed collagen fibrils in posterior capsules from injured knees of rabbits treated with the anti-fibrotic antibody is reduced significantly, (ii) treatment with the antibody-based therapeutic does not cause any side effects, (iii) the impact of the therapeutic antibody on healing of joint tissues is not significant, (iv) mechanism of action of the antibody indicates blocking collagen fibrillogenesis. Conclusion of these experiments will explain the utility and safety of the anti-collagen I antibody applied to reduce to block excessive fibrosis associated with joint injury.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2019
- Accession Number
- AD1092562
Entities
People
- Andrzej Fertala
Organizations
- Thomas Jefferson University