Peptidylarginine Deiminase 2 and Citrullination of IgG in Immunity and Rheumatoid Arthritis
Abstract
The purpose of this application is to identify mechanisms by which peptidylarginine deiminases (PADs) and citrullination regulate antibodies in immunity and rheumatoid arthritis. To this end, this project will (1) determine how PADs and IgG citrullination regulate a normal antibody response to immunization and normal antibody-based immunity to influenza, (2) identify how PADs and citrullinated IgG pathologically contribute to rheumatoid arthritis, and (3) determine if smoking increases IgG citrullination leading to autoimmune antibodies in genetically susceptible people. In the first year of this award, all administrative protocols were approved and experiments were initiated and are progressing well. No sets of experiments have been completed and there are no findings to report and discuss at this time.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2019
- Accession Number
- AD1092578
Entities
People
- Miriam A. Shelef
Organizations
- University of Wisconsin–Madison