Development of Tethered Hsp90 Inhibitors Carrying Radioiodinated Probes to Specifically Discriminate and Kill Malignant Breast Tumor Cells

Abstract

Our work this year focused on continued development of our chemistry platform with the synthesis of a novel photo-acoustic tethered Hsp90 inhibitor. Our goal is to enable this probe for PET imaging by introducing an iodine. This probe combination will have better utility for interfacing our technology with current standard of practice mammography programs. Pharmacokinetic studies with 124IHS-227, a Cy5 carrying radioiodinated tethered Hsp90 inhibitor, showed very rapid clearance following injection into tumor bearing mice. Our studies suggest that large bolus doses or infusion are required to enable effective tumor detection by PET/CT.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2018
Accession Number
AD1093137

Entities

People

  • Timothy Haystead

Organizations

  • Duke University

Tags

DTIC Thesaurus Topics

  • Biliary System
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Chemistry
  • Cyanine Dyes
  • Department Of Defense
  • Detection
  • Diseases And Disorders
  • Neoplasms
  • Positron Emission Tomography
  • Positron Emissions
  • Radiation
  • Radiotherapy
  • Standards

Fields of Study

  • Chemistry
  • Medicine

Readers

  • Immunology
  • Medical Imaging.
  • Oncology