DAMP-Mediated Innate Immune Failure and Pneumonia After Trauma
Abstract
Lung infection is extremely common after injury. Injuries like combat wounds are linked to infections distal from the injury site due in part to release of specific molecules called Damage Associated Molecular Patterns (DAMPs). Cellular injury renders the host immunologically susceptible to infection. After major injury, DAMP release alters immune responses creating a systemic environment that is permissive of infection. This program collectively studies the production of multiple DAMPs in clinical trauma patient populations that have been aligned with highly specific laboratory models. This approach allows mechanistic studies by which production of DAMPs, released as a result of tissue injury, predisposes the host to pneumonia. Importantly, we are developing novel therapeutic treatment strategies and deliverables that will reduce the incidence of acute lung injury and promote recovery from trauma.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2018
- Accession Number
- AD1093189
Entities
People
- Carl J. Hauser
- Daniel Talmor
- Jamie Lederer
- Leo E Otterbein
- Michael Yaffe
- Simon G. Robson
Organizations
- Beth Israel Deaconess Medical Center