Genetic Variations in SLCO Transporter Genes Contributing to Racial Disparity in Aggressiveness of Prostate Cancer
Abstract
The proposed studies are expected to (1) identify genetic variations in the genes of androgen transporters that are associated with the racial differences in prostate cancer aggressiveness; (2) identify key androgen transporters of which the expression and/or the alteration of expression in cancer relative to benign prostate tissue are associated with racial differences in prostate cancer aggressiveness. Progress in the reporting period includes: 1) Completion of genotyping for all 11 SLCO members using PCaP DNA samples; 2)Finish data processing and preliminary data analyses for genotyping, and identified SNPs that may be associated with prostate cancer characteristics; 3) Continued RNA Scope analysis of SLCO transporter in prostate cancer tissue sections and discover unique cell type-specific expression of a SLCO transporter; 4) Further delineation of androgen uptake mechanism on molecular levels.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2019
- Accession Number
- AD1093276
Entities
People
- Yue Wu