Discovery and Characterization of PRCAT47: A Novel Prostate Lineage and Cancer-Specific Long Noncoding RNA

Abstract

The overall goal of this project is to characterize the functioning mechanism, utility and therapeutic potential of the biomarker PRCAT47 in prostate cancer. During this second period, we investigated the regulatory effect of PRCAT47 on androgen receptor (AR)transcript stability. We also interrogated the role of PRCAT47 in regulating HuR/TIAR-targeted mRNAs. Utilizing a novel RNA in situ hybridization technology optimized within the first period which allows us to assess PRCAT47 expression in prostate tissues, we have not evaluatedPRCAT47 expression in prostate cancer tissue microarrays by RNA-ISH and demonstrate an association with prostate cancer progression. Finally, we also assessed the therapeutic potential of PRCAT47 using cell line models and patient derived organoid cultures.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2019
Accession Number
AD1093352

Entities

People

  • Rohit Mehra

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Biological Sciences
  • Cell Line
  • Cells
  • Chemistry
  • Computer Science
  • Data Science
  • Gene Expression
  • Genetics
  • Information Processing
  • Information Science
  • Medical Personnel
  • Neoplasms
  • Network Science
  • Prostate Cancer
  • Rna Stability
  • Statistical Analysis

Fields of Study

  • Biology

Readers

  • Oncology and Biomarker-Based Cancer Detection.
  • Prostate Cancer Biology.