Development of a Prognostic Marker for Lung Cancer Using Analysis of Tumor Evolution

Abstract

The goal of this project is to sequence the exomes of single tumor cells from tumors in order to construct evolutionary trees, the characteristics of which will be used to predict whether a tumor will metastasize or not. Since the last annual report, we continued to collect fresh lung tumor specimens, process them into single cell suspensions, and isolate and amplify DNA for sequencing. Laboratory Corporation of America (LabCorp) took over the sequencing for this project, and all sequencing is complete. We have received all the data and are in the midst of data processing, mutation analysis, and construction of phylogenetic trees

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2018
Accession Number
AD1093538

Entities

People

  • Edward F. Jr Patz

Organizations

  • Duke University

Tags

DTIC Thesaurus Topics

  • Best Practices
  • Biomedical Research
  • Cancer
  • Cell Physiological Processes
  • Data Processing
  • Dna Sequence Analysis
  • Flight Training
  • Genetics
  • Genome
  • Lung Cancer
  • Maryland
  • Neoplasms
  • Organizational Structure
  • Personal Information Managers
  • Sequence Analysis
  • Training
  • Universities

Fields of Study

  • Biology

Readers

  • Government Contracting/Procurement.
  • Molecular Biology and Genetics
  • Molecular and genetic basis of cancer.