Assessing Bacteriophage and Antibiotic Combinations for Synergy Against Multidrug Resistant Wound Infection Pathogens

Abstract

The objective of this proposal is to study phages used in combination with antibiotics to treat biofilm infections. In vitro biofilm assays were completed to assess phage plus antibiotic combinations. Synergistic combinations were found; some resulted in reduced biomass of biofilm, others resulted in reduced number of live bacteria in the biofilm. These differences may be due to the mechanism of action of the antibiotics and should be investigated further. These in vitro data suggest that combinations of phage plus antibiotic may reduce biofilm in an in vivo setting. Assessment of synergistic pairs will be completed in animal models during the next funding period.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2018
Accession Number
AD1093592

Entities

People

  • Anna C. Jacobs

Organizations

  • Walter Reed Army Institute of Research

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Bacteria
  • Bacterial Infections
  • Bacteriophages
  • Biomedical Research
  • Electronic Mail
  • Indicator Dyes
  • Infection
  • Infectious Diseases
  • Microorganisms
  • Professional Development
  • Standards
  • Staphylococcus Aureus
  • Virus Diseases
  • Viruses
  • Wound Infections
  • Wounds And Injuries

Fields of Study

  • Biology

Readers

  • Microbial Pathology
  • Oncology

Technology Areas

  • Biotechnology