MicroRNA in Prostate Cancer Racial Disparities and Aggressiveness

Abstract

We examined the association of plasma miRNA levels and inherited polymorphisms in genes in the microRNA (miRNA) biogenesis pathway with prostate cancer aggressiveness among African American (AA) and European American (EA) men with prostate cancer (PCa) from the Karmanos Cancer Institute in Detroit, MI. We demonstrated that a previously unreported circulating miRNA signature consisting of two distinct combinations of miRNAs (miR-17/miR-192) and (miR-146a/miR-20a/miR26b) is capable of segregating aggressive and non-aggressive prostate cancer in both AA and EA patients. When we evaluated SNPs in genes involved in the miRNA biogenesis pathway, multiple SNPs in TARBP1, DROSHA and DICER1 were significantly associated with PCa aggressiveness in AA men. Fewer SNPs were significantly associated with PCa aggressiveness in EA men, and were primarily located in TARBP1 and DROSHA. Only 1 SNP was significant for both the AA and EA adjusted analyses: rs4920247, which is an intronic SNP located in TARBP1.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2018
Accession Number
AD1093593

Entities

People

  • Cathryn Bock

Organizations

  • Wayne State University

Tags

DTIC Thesaurus Topics

  • Accuracy
  • Apoptosis
  • Biomedical Research
  • Blood
  • Cell Physiological Processes
  • Cells
  • Computational Biology
  • Computational Science
  • Computer Programming
  • Databases
  • Gene Expression
  • Genetics
  • Health Services
  • Information Science
  • Medical Personnel
  • Neoplasms
  • Statistics

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.