Iron Chelation Enhances TAM and Triple-Negative Breast Cancer Cell Death

Abstract

The goal of this study is to complete preclinical testing of Deferiprone (DFP), an iron chelator in clinical use for nononcologic diseases. We propose to demonstrate the sensitivity of TNBC to DFP as a single agent, and in combination with immune modulation therapy (checkpoint inhibitors) and chemotherapy (paclitaxel). We will determine if imaging of changes in iron content using magnetic resonance imaging can serve as a biomarker of DFP efficacy. Studies were planned to be performed sequentially by first studying in vitro effects of DFP, followed by in vivo effects, followed by the effects of adding other drugs (checkpoint inhibitors and paclitaxel). Effects of these drugs on cell cycle and immune effects were also proposed.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2018
Accession Number
AD1093771

Entities

People

  • Jason A Koutcher
  • Ronald Blasberg

Organizations

  • Sloan-Kettering Institute

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Biomedical Research
  • Blood
  • Breast Cancer
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Contrast Media
  • Cyanides
  • Diseases And Disorders
  • Lymphocytes
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Medical Personnel
  • Metabolic Diseases
  • Neoplasms

Fields of Study

  • Medicine
  • Physics

Readers

  • Analytical Chemistry
  • Oncology
  • Wave Propagation and Nonlinear Chaotic Dynamics.