Optimizing Skin-Implant Interface of Osseointegrated Device

Abstract

This study focuses on an OI prosthetic implant anchored in the long bone of a residual limb and exiting through the skin. Implant and soft-tissue infections and implant loosening are common complications for both upper and lower extremity bone-anchored implants, resulting in revision surgeries and increased morbidity. We explore the possibility of creating a tight, durable skin-implant interface for OI implants using mesenchymal stem cells (MSCs) derived from naturally occurring porcine integumentary tissues or human induced pluripotent stem (iPS) cells, which have the intrinsic potential to form an impervious seal at hard and soft tissue junctions. Initial porcine cell characterization is ongoing.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2018
Accession Number
AD1093791

Entities

People

  • Joan Bechtold
  • Jonathan Forsberg
  • Thomas A. Davis

Organizations

  • Henry M. Jackson Foundation for the Advancement of Military Medicine

Tags

DTIC Thesaurus Topics

  • Adhesion
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Biological Staining And Labeling
  • Biomedical Research
  • Bone Marrow
  • Cells
  • Gene Expression
  • Infection
  • Medical Personnel
  • Prostheses And Implants
  • Prosthetics
  • Soft Tissues
  • Stem Cells
  • Teeth
  • Tendons
  • Wound Infections

Readers

  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology