Defining Hepatocellular Carcinoma Subtypes and Treatment Responses in Patient-Derived Tumorgrafts

Abstract

Hepatocellular carcinoma (HCC) is the 6th most common cancer and 3rd leading cause of cancer-related death worldwide. We know that HCC subtypes exist because clear clinical, radiographic, and histological differences between patients with HCC are observed. In this study we proposed to investigate distinct subtypes of HCC using a mouse-human chimeric Patient Derived Xenograft (PDX) approach. So far, we have performed a large effort to implant 102 tumors from human HCC patients from Texas. We have established the protocol and the results have taught us that engraftment using a variety of transplantation techniques will result in a 25-30 percent engraftment efficiency for early stage surgical tumors. We have established 6 new human HCC PDX models that will be highly relevant for therapeutic and biological studies. These represent North American HCCs, including some patients with intermediate/advanced stage HCC, which is a unique resource for the field.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2018
Accession Number
AD1093809

Entities

People

  • Adam Yopp
  • Akbar K Waljee
  • Amit Singal
  • Daniel J Siegwart
  • Hao Zhu

Organizations

  • Veterans Education and Research Association of Michigan

Tags

DTIC Thesaurus Topics

  • Biology
  • Biomedical Research
  • Cancer
  • Carcinoma
  • Data Analysis
  • Department Of Defense
  • Diseases And Disorders
  • Genetics
  • Hepatitis
  • Information Science
  • Liver Diseases
  • Machine Learning
  • Medical Personnel
  • Neoplasms
  • Predictive Modeling
  • Therapy
  • Xenografts

Fields of Study

  • Medicine

Readers

  • Oncology (Cancer Research).
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology