Reduced GABAergic Tonic Inhibition as a Shared Mechanism of Post-Traumatic SleepDisorders and Epilepsy

Abstract

TBI is the signature injury in Veterans from recent wars and over 1.5 million Americans sustain TBI each year. Whether from a mild, moderate, severe, or repetitive insult, TBI may lead to a series of complications including PTE, SWD, and MD such as post-traumatic stress disorder (PTSD) and depression. Across the spectrum of TBI severity, PTE occur in up to40%, SWD 30-70% and MD in 35-40% of patients. In many patients, PTE and SWD occur simultaneously and chronically, further contributing to mood and cognitive disorders, and a negative impact on quality of life.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2019
Accession Number
AD1093835

Entities

People

  • Rama Maganti

Organizations

  • University of Wisconsin System

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anxiety Disorders
  • Biomedical Research
  • Brain
  • Brain Injuries
  • Data Analysis
  • Depression
  • Detection
  • Diseases And Disorders
  • Electrodes
  • Epilepsy
  • Medical Personnel
  • Mood Disorders
  • Neurosciences
  • Public Health
  • Sleep Disorders
  • Students
  • Traumatic Stress Disorder

Fields of Study

  • Medicine
  • Psychology

Readers

  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.