Encoding of Multiple Reward-Related Computations in Transient and Sustained High-Frequency Activity in Human OFC
Abstract
Human orbitofrontal cortex (OFC) has long been implicated in value-based decisionmaking. In recent years, convergent evidence from human and model organisms has further elucidated its role in representing reward-related computations underlying decision making. However, a detailed description of these processes remains elusive due in part to (1) limitations in our ability to observe human OFC neural dynamics at the timescale of decision processes and (2) methodological and interspecies differences that make it challenging to connect human and animal findings orto resolve discrepancies when they arise. Here, we sought to address these challenges by conducting multi-electrode electrocorticography (ECoG) recordings in neurosurgical patients during economic decision making to elucidate the electrophysiological signature, sub-second temporal profile, and anatomical distribution of reward-related computations within human OFC.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 13, 2018
- Accession Number
- AD1093882
Entities
People
- Arjen Stolk
- Edward Chang
- Gerwin Schalk
- Ignacio Saez
- Jack Lin
- Josef Parvizi
- Ming Hsu
- Robert T. Knight
Organizations
- University of California, Berkeley