Macrophage Polarization and Utility of in Vivo Therapy with a Brain-Permeable Anti-TNF Agent in Models of Autism

Abstract

Human studies and animal models suggest that maternal immune activation (MIA) can have lasting effects on the offsprings neurodevelopment, immune set points, and behavior. The overall goal of this proposal is to define relevant signaling pathways and identify molecular targets and developmental windows for intervention and treatment. During this period, we ordered and expanded the TNFR1R2 DKO mice from Jackson labs on site. The mice are breeding and we plan to colonize them with stool of the Taconic C57Bl/6N mice so that they will be responsive to the viral mimetic we plan to use. We began work on Aim 4 because it did not involve use of transgenic mouse colonies and pharmacological studies are underway to interrogate the role of soluble TNF in the MIA model of ASD.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2019
Accession Number
AD1093891

Entities

People

  • Mariadelourdes Tansey

Organizations

  • Emory University

Tags

DTIC Thesaurus Topics

  • Autism
  • Blood
  • Breeding
  • Cells
  • Dementia
  • Diseases And Disorders
  • Experimental Design
  • Genes
  • Genetic Phenomena
  • Genetics
  • Health Services
  • Medical Personnel
  • Microbiomes
  • Neurodegeneration
  • Parkinson'S Disease
  • Statistical Analysis
  • Students

Readers

  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Immunology and Pathology
  • Infectious Disease/Epidemiology