Pharmacology of Polycystic Kidney Disease Proteins
Abstract
The primary goal of this proposal is to identify regulators, in particular activators, of PKD1 and PKD2 proteins for future pharmacological dissection of their structures and functions that will shed light on pathogenesis of ADPKD. Aim 1: Identify small molecule activators of PKD proteins by liposome flux assay. Aim 2: Identify cone snail peptide regulators of PKD proteins. Aim 3: Generate conformation-sensitive, functional antibodies for PKD proteins.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2019
- Accession Number
- AD1093920
Entities
People
- Erhu Cao
Organizations
- University of Utah