Integrated Genomic Biomarkers to Identify Aggressive Disease in African Americans with Prostate Cancer

Abstract

Robust methods for risk stratification of prostate tumors are needed to enable men and their physicians to safely select between post-treatment surveillance and immediate adjuvant therapy. The purpose of our research is to use a multi-omic approach to identify somatic copy number alterations and methylation markers in the primary tumors of African American men that can serve as a component of their recurrence risk assessment and be applied in treatment planning to help reduce the racially disparate rates of mortality from CaP. Through whole genome copy number alteration and methylation scans, the study will identify individual and integrated DNA-based biomarkers of biochemical recurrence in 200 African American men (100 with and 100 without biochemical recurrence). These biomarkers will then be validated in an independent set of 200 African American men.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2019
Accession Number
AD1093996

Entities

People

  • Albert M Levin

Organizations

  • Henry Ford Health

Tags

DTIC Thesaurus Topics

  • African Americans
  • Breast Cancer
  • Data Analysis
  • Data Mining
  • Data Science
  • Data Sets
  • Databases
  • Department Of Defense
  • Genetics
  • Health Services
  • Information Science
  • Medical Personnel
  • Physicians
  • Prostate
  • Prostate Cancer
  • Quality Control
  • Risk

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