Harnessing Neuroplasticity to Promote Rehabilitation: CI Therapy for TBI
Abstract
This study evaluated Constraint-Induced Movement (CI) therapy for promoting motor recovery in veterans and civilians with traumatic brain injury (TBI). This form of physical rehabilitation has been shown to substantially improve motor function after brain injury not due to trauma and to provoke a widespread neuroplastic response in the brain. This single blind, randomized controlled trial (N = 40) compared CI therapy for improving use of the more-affected arm in adults with TBI to a holistic fitness program named Lakeshore Enriched Fitness Training (LEFT). In addition to assessing changes from pre-treatment in more-affected arm motor function at post-treatment and 1-year afterwards, changes were examined in white matter, grey matter, and functional brain activity. Products at the end of the four years of this blinded study were a manual of procedures, a method for generating synthetic neuroimaging data for the purpose of evaluating the sensitvity of the techniques proposed for quantifying changes in grey matter, and a manuscript on the study protocol.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2018
- Accession Number
- AD1094136
Entities
People
- Edward Taub
- Gitendra Uswatte
Organizations
- University of Alabama at Birmingham