Investigation of Metabolism in Hypertrophic Cardiomyopathy
Abstract
In Year 1, we compiled metabolite profiles from heart tissue in 2 mouse models of hypertrophic cardiomyopathy (HCM) in the pre-clinical stage of disease (5 week old mice). Using GC-TOF, only 1 metabolite was significantly lower in MyHC mutants compared to littermate controls at baseline. In contrast, we found differences in levels of 13 metabolites in TnT mutants when compared to littermate-controls. Taken together, our results suggest allele-specific differences in metabolic remodeling at the preclinical stage of HCM in mouse models.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2019
- Accession Number
- AD1094190
Entities
People
- Maria R. Abraham
Organizations
- University of California Regents