Does TBI Affect mtDNA Heteroplasmy
Abstract
This collaborative project seeks to better understand the long-term consequences of traumatic brain injury (TBI) as they pertain to Alzheimers disease (AD). We propose that a traumatic brain injury (TBI) accelerates the age-related accumulation of mitochondrial DNA (mtDNA) microheteroplasmic mutations, and that this will explain the recognized association between TBI and Alzheimers disease (AD). The projects specific aims are (1) to test whether a young adulthood controlled cortical injury (CCI) accelerates the age-dependent accumulation of mtDNA mutations, (2) to test whether brain mtDNA heteroplasmy in aged mice subjected to a young adulthood CCI injury relates to behavioral function, brain metabolism, and brain structure, and (3) to test the relationship between age-related accumulation of mtDNA mutations and neurofibrillary tangles in a genetically engineered strain of mice (rTg4510). We anticipate that findings from this study will help to explain why sustaining a TBI during young adulthood increases ones late-life risk of developing AD.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2019
- Accession Number
- AD1094232
Entities
People
- Janna L. Harris
- Russell H. Swerdlow
Organizations
- University of Kansas Medical Center