Cancer Risks Associated with Inherited Mutations in Ovarian Cancer Susceptibility Genes Beyond BRCA1 and BRCA2

Abstract

Ovarian, peritoneal and fallopian tube carcinomas (OC) are the most deadly of the gynecological cancers. Our data indicate that at least 20 percent of unselected OC is hereditary and that 20-25 percent of inherited mutations occur in genes other than BRCA1 and BRCA2. The large fraction of OC associated with inherited mutations in a variety of genes provides an important opportunity to reduce OC mortality. Maximizing the benefit from OC risk assessment and prevention requires an improved understanding of the penetrance of OC genes beyond BRCA1/2. Furthermore, minimal data exist regarding the hereditary component of OC, including BRCA1/2, in non-white populations. Our study defined the genetic causes of hereditary OC in African Americans (AA) as well as the spectrum of cancers, the age of onset, and the relative risk associated with mutations in non-BRCA1/2 genes.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2019
Accession Number
AD1094239

Entities

People

  • Elizabeth M Swisher

Organizations

  • University of Washington

Tags

DTIC Thesaurus Topics

  • African Americans
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Caucasians
  • Electronic Mail
  • Genetic Testing
  • Genetic Variation
  • Mutations
  • Neoplasms
  • Ovarian Cancer
  • Professional Development
  • Risk
  • Sequences
  • Spectra
  • Technology Transfer
  • Tubes

Fields of Study

  • Medicine

Readers

  • Molecular Genetics
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology