VIPER: Chronic Pain after Amputation: Inflammatory Mechanisms, Novel Analgesic Pathways, and Improved Patient Safety

Abstract

Chronic pain is a significant problem after nerve injury from trauma or surgery. Current therapies and attempts at prevention have proven largely ineffective. Through analysis of data obtained in the Molecular Signatures of Chronic Pain Subtypes study termed Veterans Integrated Pain Evaluation Research(VIPER) (W81XWH-11-2-0003) we have discovered two novel pain pathways with potential therapeutic relevance (Wnt and TGR5). In addition, we recognize that improving the safety and efficacy of existing therapies must continue to be a priority and plan to use the large pharmacogenomic database at Vanderbilt University to identify patients at risk for adverse opioid related events. The current proposal intends to study the contribution of non-neuronal immune cells (macrophages) to chronic pain while also evaluating novel analgesics in relevant animal models. The current proposal also attempts to determine the optimal patient population for opioid therapy while identifying those patients at greatest risk from opioids.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2018
Accession Number
AD1094283

Entities

People

  • Thomas Van De Ven

Organizations

  • Duke University

Tags

DTIC Thesaurus Topics

  • Amputation
  • Analgesics
  • Astrocytes
  • Cells
  • Culture Techniques
  • Data Analysis
  • Databases
  • Diseases And Disorders
  • Macrophages
  • Medical Personnel
  • Pain
  • Peripheral Nervous System
  • Residual Limbs
  • Respiration Disorders
  • Surgery
  • Surgical Amputations
  • Universities

Fields of Study

  • Medicine

Readers

  • Molecular and Cellular Biology
  • Neurotrauma and Rehabilitation Medicine.