Novel Listeria Vectors Secreting Gut Flora-Altering Agents to Prevent Colon Cancer and Treat Colitis
Abstract
We defined effects of the immune co-signaling molecule B7-H1 on colitis and cancer development, and effects on immune events in colon. Specific objectives. 1. Define the effects of colon B7-H1 on colitis and development of colon cancer. 2. Test if altering colon B7-H1 signals using recombinant Listeria could affect colitis and subsequent colon cancer. Significant results or key outcomes. We have shown that hostB7-H1 and gut B7-H1 contribute to colitis and colon cancer development. These data provide the proof of concept that targeting this molecule can help reduce colon cancer or treat it. We showed that conventional T cells can induce colon cancer and unconventional T cells can inhibit colon cancer. We showed that B7-H1 alters the gut microbiome to alter colitis and cancer. These data help understand colon cancer immunopathogenesis for future prevention/treatment approaches. We identified specific immune molecules and cells participating in colitis and colon cancer to inform further studies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2018
- Accession Number
- AD1094290
Entities
People
- Peter Dube
- Tyler J Curiel
Organizations
- University of Texas at San Antonio