Furanyl Fatty Acid Inhibition of FABP5 as a Mechanism for Treatment and Prevention of Cancer

Abstract

We propose that inhibition of FABP5 represents a novel approach to diverting endogenous RA from pro-proliferative (PPAR delta) to anti-proliferative (RAR) receptors, and further propose the use of furan-containing fatty acids as agents to target RA to RAR. We hypothesize that this pharmacologic inhibition will prevent the oncogenic effects of FABP5 overexpression in highly relevant breast cancer models that display a high ratio of FABP5: CRABP-II expression.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2018
Accession Number
AD1094323

Entities

People

  • Gregory P Tochtrop

Organizations

  • Case Western Reserve University

Tags

DTIC Thesaurus Topics

  • Acids
  • Antineoplastic Agents
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Carrier Proteins
  • Cell Line
  • Cells
  • Chemical Synthesis
  • Fatty Acids
  • Inhibition
  • Instructors
  • Metabolism
  • Molecules
  • Neoplasms
  • Small Molecules
  • Students

Readers

  • Breast cancer cell signaling and growth regulation.
  • Prostate Cancer Biology.
  • Regression Analysis.