Improving Ischemia Reperfusion Injury in Vascularized Composite Tissue Allotransplantation Via Histone Deacetylase Modulation

Abstract

This work proposes to investigate the impact of histone deacetylase (HDAC) drug inhibition or deletion on the tolerance of limb warm and cold ischemia reperfusion injury (IRI) in scenarios relevant to limb transplantation using mouse models for experimentation. Limitations in tolerated ischemia times limits the scope of donors that can be considered for any particular vascularized composite allotransplant (VCA) recipient. Mitigating IRI therapeutically would have significant impact on the applicability of VCA to military personnel suffering catastrophic limb or tissue loss.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2018
Accession Number
AD1094331

Entities

People

  • Matthew H. Levine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Allografts
  • Biomedical Research
  • Composite Materials
  • Enzyme Inhibitors
  • Governments
  • Health Services
  • Inhibition
  • Ischemia
  • Medical Personnel
  • Military Personnel
  • Patent Applications
  • Professional Development
  • Students
  • Transplantation
  • Transplants
  • Vascular Diseases

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Cardiovascular Physiology
  • Neuroscience

Technology Areas

  • Biotechnology