Endogenous and Exogenous Pericytes in the Pathobiology and Treatment of Osteoarthritis

Abstract

Pdgfrb transgenic reporter animals represent a tool for the visualization of pericytes within joint associated tissues. Destabilization of the medial meniscus in the mouse induces osteoarthritic changes associated with dynamic changes in the vasculature and Pdgfrb reporter activity within the infrapatellar fat pad. These changes implicate endogenous pericytes as a key cellular player in post-traumatic osteoarthritis.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2019
Accession Number
AD1094420

Entities

People

  • Aaron W James

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Arthritis
  • Biomedical Research
  • Blood Vessels
  • Cartilage
  • Cells
  • Cells (Biology)
  • Department Of Defense
  • Disease Attributes
  • Diseases And Disorders
  • Electronic Mail
  • Growth Factors
  • Joint Diseases
  • Joints (Anatomy)
  • Medical Personnel
  • Microvessels
  • Stem Cells
  • Tissues

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Neurotrauma and Rehabilitation Medicine.