Extremity Regeneration of Soft Tissue Injury Using Growth Factor-Impregnated Gels

Abstract

Due to contamination of coccidioidomycosis within the animal facility, there was a delay of four months. Despite this, seven swine surgeries have been performed during this period, totaling 12 since the start of this study. We have now begun testing the optimal dose of VEGF and IGF in addition to completing the optimal ischemia studies. A total of five swine have been followed to completion at four months post-operatively. We continue to refine our post-operative protocol to minimize insensate traumas which have led to wound necrosis and ultimately euthanasia of four swine. Ongoing studies to evaluate nerve and vessel regeneration continue to be tested. There has been ongoing research and development on the alginate gels and growth factors through collaboration with the Wyss Institute.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2018
Accession Number
AD1094466

Entities

People

  • Sarah E. Kinsley
  • Simon G. Talbot

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Growth Factors
  • Health Services
  • Lymphocytes
  • Materials Science
  • Medical Personnel
  • Surgery
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Neurotrauma and Rehabilitation Medicine.
  • Toxicology/Environmental Toxicology