Identification of lncRNAs Required for Synthetic Lethal Interactions with Mutant KRAS in Pancreatic Cancer

Abstract

The major goal of this application is to identify lncRNAs involved in synthetic lethal interaction with KRAS in pancreatic cancer. There are two specific aims. The first aim is to screen for synthetic lethal interactions between lncRNAs and KRAS using the genome-wide CRISPR/Cas9-based lncRNA libraries. The second aim is functional characterization of candidate synthetic lethal lncRNAs in pancreatic cancer. The success of this study will help identify novel biomarkers and develop a better strategy for pancreatic cancer treatment.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2019
Accession Number
AD1094473

Entities

People

  • Yin-Yuan Mo

Organizations

  • University of Mississippi Medical Center

Tags

DTIC Thesaurus Topics

  • Biological Markers
  • Biomedical Research
  • Bladder Cancer
  • Breast Cancer
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Department Of Defense
  • Diseases And Disorders
  • Electronic Mail
  • Identification
  • Infection
  • Information Operations
  • Neoplasms
  • Ovarian Cancer
  • Rna Stability
  • Stem Cells

Fields of Study

  • Biology
  • Chemistry

Readers

  • Oncology

Technology Areas

  • Biotechnology