FYN is a Key Regulator of Metastasis in Prostate Cancer
Abstract
FYN is a member of SRC-family of kinases that has been found to be particularly unregulated in aggressive prostate cancer. Early work in this study identified its role in promoting metastasis, but later work has highlighted the role of FYN in those cancers with neuroendocrine/neural differentiation- a phenomenon seen in treatment-induced small cell neuroendocrine cancers (tSCNC), a result of strong pressure on the AR-axis. Related to this behavior, we identified a subset of circulating tumor cells (CTCs) noted by particularly small nuclei (i.e. less than 8.5 micrometer) that suggest that this type of tSCNC biology and thus clinical behavior (visceral metastasis) is at hand. Due to its high levels of FYN expression in lymphocytes, FYN expression could not be well characterized on the CTCs. Newer efforts will now focus on detecting molecular pathways downstream of FYN to better characterize this circulating biomarker which may better identify patients who would benefit from FYN inhibition as part of a therapeutic strategy.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 16, 2019
- Accession Number
- AD1094560
Entities
People
- Edwin M Posadas
- Hao Ho
- Hsian-Rong Tseng
- Jake Lichterman
- Jiaoti Huang
- Jiefu Chen
- Ker C. Li
- Leland W. Chung
- Min Song
- Yi-tseng Lu
- Zunfu Ke
Organizations
- Cedars-Sinai Medical Center