Early Recognition of Chronic Traumatic Encephalopathy Through FDDNP PET Imaging

Abstract

The PET biomarker, F-FDDNP (2-(1-{6-[(2-[F-18]fluoroethyl(methyl)amino]-2-naphthyl}ethylidene) malononitrile) [FDDNP] has shown sensitivity for in vivo detection of tau in addition to -sheet-containing brain amyloid neuroaggregates. Tau protein in a characteristic distribution is felt to be the cardinal pathologic feature of Chronic Traumatic Encephalopathy. This project will examine whether FDDNP PET imaging correlates with, and/or can predict, decline in cognitive function in those exposed to cumulative head trauma. All operational aspects of this study have been accomplished including local IRB approval, identification of potential subjects from the Professional Fighters Brain Health Study to recruit, logistics of the study visit and PET FDDNP imaging, case report forms, and electronic data entry. Actual enrollment of subjects has been delayed awaiting approval from the Human Research Protection Office.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2018
Accession Number
AD1094581

Entities

People

  • Charles Bernick

Organizations

  • Icahn School of Medicine at Mount Sinai

Tags

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Biological Markers
  • Biomedical Research
  • Brain
  • Brain Injuries
  • Brain Stem
  • Cerebellum
  • Chronic Encephalopathy
  • Detection
  • Diseases And Disorders
  • Identification
  • Logistics
  • Positron Emission Tomography
  • Positron Emissions
  • Recognition
  • Sensitivity

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.

Technology Areas

  • Microelectronics