Development of in vivo Biomarkers for Progressive Tau Pathology after Traumatic Brain Injury
Abstract
To assess extracts from the brains of human tau transgenic mice subjected to experimental traumatic brain injury for tau aggregating activity in a cell-based assay. To determine whether mouse blood and cerebrospinal fluid tau aggregating activity quantitatively predicts brain tau pathology and neurodegeneration in mouse models of chronic traumatic encephalopathy. To test whether antibodies that block tau aggregating activity and propagation of aggregates in cultured cell-based assays also block tau pathology and neurodegeneration in mouse models of chronic traumatic encephalopathy. This could lead to future therapeutic targets. To develop an antibody-based assay for tau aggregating activity to complement the cell-based assay.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2019
- Accession Number
- AD1094599
Entities
People
- David Brody
- Marc Diamond
Organizations
- University of Texas at Austin