Tranexamic Acid and Pharmacokinetics in Severe Traumatic Injury

Abstract

The major accomplishments have been the completion of patient enrollment and analysis of the data for the primary manuscript. We are currently writing the manuscript and in the process of considering which secondary analyses to work on after the submission of the primary manuscript. Preliminary major findings are the pharmacodynamics results indicate a volume of distribution of 15.6 L/70kg and clearance of 113 ml/min/70kg.There were no differences in organ failure or mortality between the 3 study groups, but there was an increase inVTE. VTE was increased in the 2 and 4 gram TXA dose groups compared to placebo. This relationship was maintained after adjusting for potential confounders. There were no differences between immune and hemostatic parameters measured between the three study groups.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2018
Accession Number
AD1094627

Entities

People

  • Grant V. Bochicchio
  • Philip C Spinella

Organizations

  • Washington University in St. Louis

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Blood
  • Communities
  • Data Analysis
  • Department Of Defense
  • Emergency Medicine
  • Health Services
  • Hospitals
  • Information Operations
  • Maryland
  • Patent Applications
  • Pharmacokinetics
  • Professional Development
  • Social Media
  • Technology Transfer
  • Universities

Fields of Study

  • Medicine

Readers

  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.
  • Toxicology/Environmental Toxicology
  • Trauma Surgery or Emergency Medicine.