The Role of Histone Demethylase Jmjd3 in Immune-Mediated Aplastic Anemia

Abstract

Acquired aplastic anemia (AA) is a condition of bone marrow failure (BMF) characterized by blood pancytopenia and BM hypoplasia. In most cases, AA is an immune-mediated disorder with destruction of hematopoietic stem and progenitor cells by T cells. There is increasing evidence that CD4+ T effector cells that produce high levels of IFN- are associated with AA in patients and experimental AA mice. IFN- displays potent effects on suppressing hematopoiesis. Immunosuppressive therapy with antithymocyte globulin in combination with cyclosporin A (CsA) can induce a hematologic response in about two-thirds of AA patients. However, relapse occurs in up to 35% of AA patients when CsA is withdrawn at 6 months. Allogeneic BM transplantation (BMT) has significantly improved the survival of AA. However, graft-versus-host disease (GVHD) remains a major barrier tothe success of the procedure. Novel approaches are needed to improve the outcomes of AA treatment.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2019
Accession Number
AD1094659

Entities

People

  • Yi Zhang

Organizations

  • Temple University

Tags

DTIC Thesaurus Topics

  • Adaptive Immunity
  • Antigen-Presenting Cells
  • Biomedical Research
  • Bone Marrow
  • Cell Physiological Processes
  • Cells
  • Computer Programming
  • Diseases And Disorders
  • Governments
  • Hematologic Diseases
  • Immunity
  • Lymph Nodes
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Proteins
  • Stem Cells

Fields of Study

  • Medicine

Readers

  • Immunology
  • Immunology and Pathology
  • Prostate Cancer Biology.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech