Large Noncoding RNAs as Therapeutic Targets in IPF

Abstract

Our proposal focuses on the role of FENDRR, a developmentally regulated lincRNA that controls gene expression by affecting chromatin remodeling in Pulmonary fibrosis (PF). PF is a condition in which the normal lung anatomy is replaced by a process of active remodeling, deposition of extracellular matrix (ECM) and accumulation of myofibroblasts. This condition can be idiopathic or secondary, but invariably associated with significant mortality and morbidity. In this project we test the hypothesis that FENDRR expression maintains fibroblasts differentiation status through its effects on chromatic organization, therefore when FENDRR expression is decreased, fibrosis is facilitated through persistence of myofibroblasts.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2018
Accession Number
AD1094683

Entities

People

  • Naftali Kaminski

Organizations

  • Yale University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cells
  • Culture Techniques
  • Fibroblasts
  • Fibrosis
  • Gene Expression
  • Genes
  • Genetics
  • Governments
  • Humanities
  • Local Governments
  • Lung Diseases
  • Maryland
  • Medical Personnel
  • Patent Applications
  • Professional Development
  • Training

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Molecular Biology and Genetics