Furanyl Fatty Acid Inhibition of FABP5 as a Mechanism for Treatment and Prevention of Cancer

Abstract

We propose that inhibition of FABP5 represents a novel approach to diverting endogenous RA from proproliferative (PPAR) to anti-proliferative (RAR) receptors, and further propose the use of furancontaining fatty acids as agents to target RA to RAR. We hypothesize that this pharmacologic inhibition will prevent the oncogenic effects of FABP5 overexpression in highly relevant breast cancer models that display a high ratio of FABP5/CRABP2 expression.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2018
Accession Number
AD1094689

Entities

People

  • Gregory P Tochtrop
  • Liraz Levi

Organizations

  • Case Western Reserve University

Tags

DTIC Thesaurus Topics

  • Acids
  • Antineoplastic Agents
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Carrier Proteins
  • Cell Line
  • Cells
  • Culture Techniques
  • Fatty Acids
  • Inhibition
  • Instructors
  • Metabolism
  • Molecules
  • Neoplasms
  • Small Molecules
  • Students

Readers

  • Molecular Biology and Genetics
  • Prostate Cancer Biology.