Examination of plasma PON1 paraoxonase activity and genotype in Gulf War veterans

Abstract

The goal of this project is to evaluate the extent to which PON1192/Gulf War (GW)-related exposure interactions contribute to the risk for Gulf War Illness (GWI), as defined by the Centers for Disease Control and Prevention (CDC) and Kansas case definitions in a large sample of GW veterans. Specifically, we will: (1) determine the associations between GWI and GW-related exposures with the potential for cholinergic effects (e.g., personal pesticide use, exposure to OP nerve agents) in subgroups of veterans with different PON1192 genotype. (2) determine the associations between GWI and each GW-related cholinergic exposure in subgroups of veterans with different PON1 activity levels and (3) calculate prevalence odds ratios for GWI/exposure associations separately for sugbroups of veterans with different PON1192 genotypes and PON1 activity levels.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2018
Accession Number
AD1094731

Entities

People

  • Linda L Chao

Organizations

  • Northern California Institute for Research and Education

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Department Of Defense
  • Department Of Veterans Affairs
  • Diseases And Disorders
  • Genetics
  • Genotypes
  • Governments
  • Institutional Review Board
  • Local Governments
  • Military History
  • Nerve Agents
  • Patent Applications
  • Persian Gulf Syndrome
  • Pesticides
  • Professional Development
  • Surface Plasmon Resonance
  • Training

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Neurotoxicology