The Cytoplasm Translocation of the Androgen Receptor Cofactor p44 as a Target for Prostate Cancer Treatment
Abstract
The over-proliferation of prostate epithelial cell is the first critical step that leads to prostate tumorigenesis. We demonstrated that p44 cytoplasm localization associates with this growth process and is essential for growth of prostate epithelial and prostate cancer cells. The proposed research tested the feasibility to target this growth process for prostate cancer treatment. We report that inhibition of p44 cytoplasm translocation by identified compounds suppressed growth and progression of prostate tumors in both tumor xenografts and Pten gen knockout mouse model. These results provided a new paradigm and anew strategy for treatment of prostate cancer. In addition, we also found that the posttranslational modifications of p44 regulated its subcellular localization during rpostate tumorigenesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2019
- Accession Number
- AD1094754
Entities
People
- Zhengxin Wang
Organizations
- Clark Atlanta University