The Pathogenesis of Post-Traumatic Pulmonary Embolism: A Prospective Multi center Investigation by the CLOTT Study Group
Abstract
Venous thromboembolism, which includes both deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common and potentially mortal complication after injury in both civilian and military settings. To date, there are no methods that have been definitively demonstrated to prevent post-traumatic pulmonary embolism (PE) which carries a mortality of 11% and is the third leading cause of death following injury. PE is particularly common among combat casualties due to the prevalence of certain risk factors such as multiple amputations, traumatic brain injury, the need for transfusions, and prolonged immobilization during evacuation. In Year 1, all subcontracts were initiated. Protocols, data collection forms and REDCap data entry system were developed. IRB and HRPO approval was attained for 15 of 17 sites participating in CLOTT Part 1. Surgical research associates were trained to screen and enroll subjects. 1,533 subjects were enrolled in CLOTT Part 1. IRB and HRPO approval was attained for 4 of 5 sites for CLOTT Part 2. Surgical research associates were trained in enrolling subjects and conducting research procedures (blood samples for thromboelastography testing. 11 subjects have been enrolled in CLOTT Part 2. There are no significant findings to report at this time.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2018
- Accession Number
- AD1094760
Entities
People
- Mary Knudson
- Michelle A. Price
Organizations
- National Trauma Institute