Blood Biomarker Profile of TBI-Associated Cognitive Impairment Among Old and Young Veterans

Abstract

The goal of this project is to define the biomarker profile of TBI-associated cognitive impairment (TBICI) in veterans and compare it to that of veterans with TBI with no CI (TBI), veterans with no TBI and CI (noTBI-CI), and to age-matched controls. Our overall hypothesis is that TBI-associated CI involves a unique biomarker profile that has features distinguishable from CI without TBI and normal aging. Examining biomarkers in exosomes from the central nervous system, we found multiple blood-based biomarkers that differed significantly between the four groups.This study refines our understanding of the underlying mechanisms in TBI-associated CI, helps predict who is at greatest risk of developing CI in veterans with TBI, and identifies who may benefit from interventions and treatment for CI and its prevention.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2019
Accession Number
AD1094784

Entities

People

  • Kristine Yaffe

Organizations

  • Northern California Institute for Research and Education

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biological Markers
  • Biomedical Research
  • Brain Injuries
  • Central Nervous System
  • Cognitive Impairment
  • Department Of Defense
  • Education
  • Information Operations
  • Military Medicine
  • Nervous System

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